Many drugs for many targets: novel treatments for complement-mediated glomerular disease

Efficient Personalized PageRank Estimation for Many Sources and Many Targets

Personalized PageRank (PPR) is a measure of the importance of a node in a graph from the perspective of another node (we call these nodes the target and the source, respectively). PPR has been used in many applications, such as offering a Twitter user (the source) personalized recommendations of who to follow (targets deemed important by PPR). Computing PPR at scale is infeasible for networks l...

Some rank equalities for finitely many tripotent matrices

‎A rank equality is established for the sum of finitely many tripotent matrices via elementary block matrix operations‎. ‎Moreover‎, ‎by using this equality and Theorems 8 and 10 in [Chen M‎. ‎and et al‎. ‎On the open problem related to rank equalities for the sum of finitely many idempotent matrices and its applications‎, ‎The Scientific World Journal 2014 (2014)‎, ‎Article ID 702413‎, ‎7 page...

MULTIPLIER ANALYSIS IN THE FRAMEWORK OF MANY PRODUCERS AND MANY CONSUMERS OF THE SAM FOR THE IRANIAN ECONOMY

Antiplatelet drugs: which targets for which treatments?

The current standard care for acute coronary syndromes is dual antiplatelet therapy combining the COX1 inhibitor aspirin with a drug targeting the P2Y12 receptor, together with anticoagulation during and after early revascularization by percutaneous intervention. In very high-risk patients, glycoprotein (GP) IIb/IIIa antagonists may also be used. Secondary prevention of ischemic events requires...

The Rotavirus Interferon Antagonist NSP1: Many Targets, Many Questions.

Rotavirus is a leading cause of death due to diarrhea among young children across the globe. Despite the limited coding capacity that is characteristic of RNA viruses, rotavirus dedicates substantial resources to avoiding the host innate immune response. Among these strategies is use of the interferon antagonist protein NSP1, which targets cellular proteins required for interferon production to...